STRUCTURAL MECHANISM FOR TYROSINE HYDROXYLASE INHIBITION BY DOPAMINE AND REACTIVATION BY SER40 PHOSPHORYLATION

Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation

Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of the catecholamine neurotransmitters and hormones dopamine (DA), adrenaline and noradrenaline.Here, the authors present the cryo-EM structures of full-length Shorts human TH in the apo form and bound with DA, as well as the structure of Ser40 phosphorylated TH, Clothing M

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Dynamic deadlock detection under the OR requirement model

Deadlock detection is one of the most discussed PURE BLACK CHERRY problems in the literature.Although several al- gorithms have been proposed, the problem is still open.In general, the correct operation of an algorithm depends on the requirement model being considered.This article introduces a deadlock detection algorithm for the OR model.The algor

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Spatial Analyses of Harappan Urban Settlements

The Harappan Civilization occupies a unique place among the early civilizations of the world with its well planned urban settlements, advanced handicraft and technology, religious and trade activities.Using a Geographical Information Systems (GIS), this study presents spatial analyses that locate urban settlements on a Signage digital elevation mod

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Evaluation of IgG4+ Plasma Cell Infiltration in Patients with Systemic Plasmacytosis and Other Plasma Cell-infiltrating Skin Diseases

Systemic plasmacytosis is a rare skin disorder characterized by marked infiltration of plasma cells in the dermis.IgG4-related disease is pathologically characterized by lymphoplasmacytic infiltration rich in IgG4+ plasma cells, storiform fibrosis, and obliterative phlebitis, accompanied by elevated levels of serum IgG4.Reports of cases of systemic

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